Research Article
General Analytical Procedure for Determination of Acidity Parameters of Weak Acids and Bases
Table 5
The p
’s values of compounds determined in the multicomponent mixture of amines, heterocyclic moiety, and weak (Mes) and strong (HCl) acids at 25°C.
| | Composition of D | pKA ± s |
p ± s | p ± s | pKFA ± s |
| | A+ HCl | 4.650 ± 0.02 | — | — | — | | A + 4NH2Py + HCl | 4.53 ± 0.04 | 9.27 ± 0.18 | — | — | | A + 4NH2Py + 2NH2Py + HCl | 5.13 ± 0.07 | 9.59 ± 0.07 | 7.18 ± 0.07 | — | | A + 2NH2Py + FA | 4.7* | — | 6.7* | 3.05 ± 0.04 | | 4.26 ± 0.02 |
| | Composition of D | pKMes ± s | p ± s | pKPy3CA ± s | pKBt ± s | | or pKPy4CA ± s | or pKBi ± s |
| | Mes + Bt | 6.24 ± 0.05 | — | — | 8.75 ± 0.59 | | Mes + 2NH2Py + Bi + HCl | 6.28 ± 0.05 | 7.22 ± 0.05 | — | 5.36 ± 0.04 | | Mes + 2NH2Py + Py3CA | 6.29 ± 0.03 | 7.22 ± 0.03 | 4.78 ± 0.03 | — | | Mes + 2NH2Py + Py4CA | 6.29 ± 0.34 | 6.39 ± 0.34 | 4.76 ± 0.30 | — |
| | Composition of D | pKASA ± s | p ± s | pKPy3CA ± s | pKAA ± s | | or pK3MePy |
| | ASA + Py3CA + AA | 3.66 ± 0.05 | — | 5.02 ± 0.04 | 4.15 ± 0.05 | | ASA + 2NH2Py + 3MePy | 3.61 ± 0.03 | 7.02 ± 0.03 | — | 5.82 ± 0.03 |
|
|
*p value const. from the literature [see Table 11].
|
