Quality Assessment of Ojeok-San, a Traditional Herbal Formula, Using High-Performance Liquid Chromatography Combined with Chemometric Analysis
Table 5
The average content of the marker compounds in OJS samples ().
Compound
Content (mg/g)
OJS01a
OJS02b
OJS03
OJS04
OJS05
OJS06
OJS07
OJS08
OJS09
OJS10
Gallic acid
0.096 ± 0.001
0.609 ± 0.023
0.978 ± 0.054
0.531 ± 0.005
0.273 ± 0.003
0.372 ± 0.004
0.371 ± 0.013
0.372 ± 0.023
1.592 ± 0.068
0.379 ± 0.006
Protocatechuic acid
0.019 ± 0.000
0.063 ± 0.001
NDc
0.032 ± 0.000
0.022 ± 0.002
0.019 ± 0.000
ND
0.018 ± 0.001
0.035 ± 0.001
0.036 ± 0.002
Chlorogenic acid
0.326 ± 0.002
0.009 ± 0.002
ND
0.333 ± 0.014
0.013 ± 0.000
0.082 ± 0.006
ND
0.028 ± 0.001
0.023 ± 0.002
0.036 ± 0.014
Albiflorin
0.184 ± 0.008
1.635 ± 0.020
5.950 ± 0.066
0.249 ± 0.010
0.243 ± 0.006
0.093 ± 0.011
5.060 ± 0.071
0.938 ± 0.017
1.072 ± 0.015
0.701 ± 0.040
Paeoniflorin
0.796 ± 0.006
3.363 ± 0.030
2.457 ± 0.046
2.294 ± 0.030
0.385 ± 0.017
1.529 ± 0.034
2.190 ± 0.048
1.679 ± 0.005
2.522 ± 0.052
1.539 ± 0.010
Ferulic acid
0.187 ± 0.000
ND
ND
0.172 ± 0.004
ND
ND
ND
ND
ND
ND
Liquiritin
0.800 ± 0.003
0.325 ± 0.008
0.259 ± 0.011
0.237 ± 0.009
0.083 ± 0.000
0.214 ± 0.005
0.014 ± 0.002
0.247 ± 0.002
0.236 ± 0.003
0.150 ± 0.003
Benzoic acid
0.337 ± 0.003
0.950 ± 0.012
0.449 ± 0.003
0.371 ± 0.007
0.244 ± 0.001
0.275 ± 0.001
1.902 ± 0.103
0.998 ± 0.005
1.612 ± 0.005
0.476 ± 0.003
Nodakenin
0.449 ± 0.002
ND
0.037 ± 0.000
0.002 ± 0.001
0.010 ± 0.000
ND
0.057 ± 0.001
0.045 ± 0.000
0.030 ± 0.001
ND
Hesperidin
3.086 ± 0.003
0.437 ± 0.013
0.348 ± 0.004
4.999 ± 0.010
0.376 ± 0.001
0.875 ± 0.006
ND
0.044 ± 0.001
0.214 ± 0.002
0.008 ± 0.002
Naringin
3.115 ± 0.002
0.578 ± 0.017
1.084 ± 0.007
2.983 ± 0.001
0.631 ± 0.001
0.783 ± 0.002
0.366 ± 0.004
0.580 ± 0.001
1.276 ± 0.004
0.750 ± 0.003
Neohesperidin
1.816 ± 0.001
0.277 ± 0.001
0.198 ± 0.001
3.139 ± 0.003
0.235 ± 0.000
0.592 ± 0.001
ND
ND
0.105 ± 0.000
0.043 ± 0.001
Ononin
0.028 ± 0.000
0.038 ± 0.000
0.022 ± 0.000
0.018 ± 0.000
0.014 ± 0.000
0.049 ± 0.000
0.004 ± 0.000
0.055 ± 0.000
0.033 ± 0.000
0.028 ± 0.000
Oxypeucedanin hydrate
0.359 ± 0.001
0.021 ± 0.001
0.052 ± 0.000
0.165 ± 0.000
0.028 ± 0.001
0.057 ± 0.000
0.005 ± 0.000
0.028 ± 0.001
0.019 ± 0.000
0.080 ± 0.001
Cinnamic acid
0.047 ± 0.000
0.033 ± 0.000
0.022 ± 0.000
0.055 ± 0.001
0.003 ± 0.000
0.011 ± 0.001
0.064 ± 0.002
0.013 ± 0.001
0.023 ± 0.000
0.041 ± 0.000
Byakangelicin
0.248 ± 0.002
0.013 ± 0.000
0.046 ± 0.000
0.071 ± 0.001
0.010 ± 0.001
0.030 ± 0.000
0.002 ± 0.000
0.016 ± 0.000
0.015 ± 0.000
0.026 ± 0.000
Cinnamaldehyde
0.083 ± 0.001
ND
0.122 ± 0.002
ND
ND
ND
ND
ND
ND
ND
Benzoylpaeoniflorin
0.019 ± 0.001
0.563 ± 0.006
0.049 ± 0.001
0.058 ± 0.004
0.005 ± 0.000
0.049 ± 0.001
0.048 ± 0.002
0.107 ± 0.001
0.052 ± 0.000
0.038 ± 0.002
Glycyrrhizin
1.155 ± 0.005
1.101 ± 0.032
0.959 ± 0.034
0.762 ± 0.044
0.248 ± 0.023
2.025 ± 0.015
1.179 ± 0.038
2.124 ± 0.028
0.790 ± 0.049
1.445 ± 0.037
The average content is represented as mean ± SD. aOJS01, Ojeok-san water extract from the laboratory, bOJS02–OJS10 = Ojeok-san granules from Korean manufacturers, and cND, not detected.
