Stability-Indicating RP-HPLC Method for Simultaneous Estimation of Enrofloxacin and Its Degradation Products in Tablet Dosage Forms

Table 10

Robustness results (flow rate and minor component change variations).

Name of the impurity	Flow rate; 1.1 mL/min		Flow rate; 0.9 mL/min		Higher methanol concentration; at 45 min to 72%		Lower methanol concentration; at 45 min to 68%
	RRT	Resolution	RRT	Resolution	RRT	Resolution	RRT	Resolution
%Decarboxylated impurity	0.55	—	0.57	—	0.54	—	0.58	—
%Desfluoro impurity	0.78	15.56	0.79	15.13	0.77	15.26	0.80	15.35
%ED impurity	0.85	3.66	0.85	4.05	0.84	3.88	0.85	3.47
%Cipro base impurity	0.95	6.14	0.96	6.00	0.95	5.77	0.95	5.76
Enrofloxacin	1.00	2.30	1.00	1.99	1.00	2.00	1.00	2.16
%Chloro impurity	1.19	16.27	1.31	15.82	1.34	15.63	1.30	15.40
%FQ acid impurity	1.85	38.26	1.76	33.95	1.93	39.33	1.70	29.50