Determination of Propranolol Hydrochloride in Pharmaceutical Preparations Using Near Infrared Spectrometry with Fiber Optic Probe and Multivariate Calibration Methods
Table 2
Results obtained using siPLS algorithm for propranolol hydrochloride determination by FTNIR/PROBE.
Model
VNa
Interval
LVb
RMSECV (mg g−1)
RMSEP (mg g−1)
PLS (MSC/M)
6000
all
5
0.955
18.4
18.6
s2i10PLS
600
3, 8
6
0.978
9.7
8.7
s2i20PLS
300
5, 16
4
0.990
8.8
8.2
s2i30PLS
200
7, 12
5
0.984
8.3
10.8
s2i40PLS
150
9, 32
4
0.984
8.3
11.7
s3i10PLS
600
3, 7, 9
6
0.979
9.6
13.7
s3i20PLS
300
5, 14, 18
7
0.983
8.7
11.5
s3i30PLS
200
7, 22, 27
8
0.983
8.5
12.0
s3i40PLS
150
9, 22, 32
9
0.986
7.9
14.5
VN: total variable numbers; bLV: latent variables.
