Development and Validation of an HPLC Method for Simultaneous Quantification of Clopidogrel Bisulfate, Its Carboxylic Acid Metabolite, and Atorvastatin in Human Plasma: Application to a Pharmacokinetic Study

Figure 2

Chromatograms of blank plasma (a); drug-free human plasma spiked with clopidogrel carboxylic acid metabolite (CCA with  min), atorvastatin (ATV with  min), IS-ibuprofen (2 μg·Ml⁻¹,  min), and clopidogrel bisulfate (CLP with  min) (b); plasma sample from a volunteer who received 75 mg clopidogrel and 40 mg atorvastatin at 40 minutes after dose under optimized gradient method at flow rate of 1 mL·min⁻¹ (c).

(a) 1,2,3,4-endogenous compounds from plasma

(b)

(c)