Development and Validation of an HPLC Method for Simultaneous Quantification of Clopidogrel Bisulfate, Its Carboxylic Acid Metabolite, and Atorvastatin in Human Plasma: Application to a Pharmacokinetic Study

Figure 6

Plasma levels of clopidogrel, its carboxylic acid metabolite, and atorvastatin versus time following administration of 75 mg clopidogrel and 20 mg atorvastatin daily (patient 1), 75 mg clopidogrel and 40 mg atorvastatin daily (patient 2), and 75 mg clopidogrel and 80 mg atorvastatin daily (patient 3).