Development and Validation of an HPLC Method for Simultaneous Quantification of Clopidogrel Bisulfate, Its Carboxylic Acid Metabolite, and Atorvastatin in Human Plasma: Application to a Pharmacokinetic Study

Table 3

Results of stability tests for clopidogrel carboxylic acid metabolite and atorvastatin.

Analyte	Stability	Nominal concentration μg·mL^−1	Mean found concentration μg·mL^−1	Recovery %	RSD %
CCA	Short-term (6 h at room temperature)	0.12	0.11 ± 0.01	92	9.09	3
		4	3.86 ± 0.15	97	3.89	3
	Long-term (30 days at room temperature)	0.12	0.11 ± 0.01	92	9.08	3
		4	3.85 ± 0.06	96	1.56	3
ATV	Short-term (6 h at room temperature)	0.5	0.47 ± 0.01	94	2.13	3
		2.5	2.41 ± 0.02	96	0.83	3
	Long-term (30 days at room temperature)	0.5	0.46 ± 0.05	92	10.87	3
		2.5	2.41 ± 0.01	96	0.42	3