Development and Validation of an HPLC Method for Simultaneous Quantification of Clopidogrel Bisulfate, Its Carboxylic Acid Metabolite, and Atorvastatin in Human Plasma: Application to a Pharmacokinetic Study

Table 4

Robustness results for the RP-HPLC method.

Parameters	CCA		ATV		CLP
	Retention time (min) ± SD	% RSD	Retention time (min) ± SD	% RSD	Retention time (min) ± SD	% RSD
Flow rate; mL·min^−1
0.9	9.75 ± 0.02	0.26	11.03 ± 0.01	0.61	12.96 ± 0.03	1.58
1	9.66 ± 0.01	0.31	10.99 ± 0.02	0.66	12.68 ± 0.01	1.57
1.1	9.44 ± 0.03	0.20	10.90 ± 0.03	0.52	12.48 ± 0.03	0.95
pH
2.6	9.66 ± 0.02	0.36	10.99 ± 0.01	0.66	12.68 ± 0.01	1.55
2.8	9.65 ± 0.01	0.20	10.93 ± 0.03	0.39	12.50 ± 0.03	0.96

: number of replicates.