Development and Validation of an HPLC Method for Simultaneous Quantification of Clopidogrel Bisulfate, Its Carboxylic Acid Metabolite, and Atorvastatin in Human Plasma: Application to a Pharmacokinetic Study

Table 5

System suitability test results for clopidogrel bisulfate, its carboxylic acid metabolite, and atorvastatin calcium by the proposed LC method.

Parameter	Obtained value			Reference value
	CCA	ATV	CLP
Analyte
Retention time (min)	9.66	10.99	12.68
Tailing factor ()	0.94	1.12	1.5	≤2.0
Plate count ()	14763	15935	18340	>2000
Resolution ()	8.75		8.82	>2.00

CLP: clopidogrel bisulfate; CCA: clopidogrel carboxylic acid metabolite; ATV: atorvastatin; SD: standard deviation; RSD: relative standard deviation.