Development and Validation of an HPLC Method for Simultaneous Quantification of Clopidogrel Bisulfate, Its Carboxylic Acid Metabolite, and Atorvastatin in Human Plasma: Application to a Pharmacokinetic Study

Table 7

Pharmacokinetic parameters for clopidogrel bisulfate, its carboxylic acid metabolite, and atorvastatin calcium.

	Elimination rate constant	Half-life
	(h^−1)	(h)	(h)	(μg·mL^−1)	(μgh/mL)	(μgh·mL^−1)
Patient 1 (clopidogrel 75 mg, atorvastatin 20 mg)
CLP	0.81	0.85	0.25	0.1	0.85	0.85
CCA	0.15	4.51	1	4.2	17.79	20.46
ATV20	0.08	8.15	3	0.09	0.67	1.03
Patient 2 (clopidogrel 75 mg, atorvastatin 40 mg)
CLP	0.58	1.20	0.25	0.08	0.63	0.63
CCA	0.23	3	1.24	4.77	19.61	21.55
ATV40	0.08	8.37	2.52	0.15	0.91	0.96
Patient 3 (clopidogrel 75 mg, atorvastatin 80 mg)
CLP	1.02	0.68	0.25	0.07	0.65	0.65
CCA	0.13	5.21	1	3.32	14.38	15.45
ATV80	0.07	9.32	3.06	0.19	1.32	1.36