Transition Metal Complexes of Naproxen: Synthesis, Characterization, Forced Degradation Studies, and Analytical Method Verification

Table 5

Degradation profile of Naproxen and its metal chelates.

Tested compounds	% of loss in acid media	% of loss in basic media	% of loss in oxidation	% of loss in reduction	% of loss in water hydrolysis	% of loss in dry heat
Naproxen	7.92	4.76	6.99	7.31	1.39	5.03
Nap-Cu complex	3.59	2.48	2.12	2.13	0.29	3.50
Nap-Co complex	2.13	1.99	2.98	2.55	0.31	3.07
Nap-Fe complex	3.75	1.72	1.68	1.86	0.01	2.65
Nap-Ag complex	4.36	3.57	4.71	3.29	0.18	4.18
Nap-Zn complex	2.50	2.26	2.02	2.42	0.05	3.78