Transition Metal Complexes of Naproxen: Synthesis, Characterization, Forced Degradation Studies, and Analytical Method Verification

Table 9

Robustness of the method.

Parameter	Samples	Retention time (min)	Tailing factor	Theoretical plate
Flow rate; (±50%); ()	Naproxen	3.121–6.675	0.564–1.134	2536–3002
	Nap-Cu	2.858–7.456	0.637–1.046	2535–3257
	Nap-Co	2.936–7.136	0.635–1.145	2504–2993
	Nap-Fe	3.012–6.546	0.537–1.267	2245–2866
	Nap-Ag	2.789–7.245	0.563–1.046	2536–3658
	Nap-Zn	2.977–6.896	0.682–1.035	2546–3527
Solvent ratio; (±30%); ()	Naproxen	3.234–6.789	0.456–1.464	2454–3013
	Nap-Cu	3.567–5.346	0.523–1.368	2575–2935
	Nap-Co	3.786–5.359	0.684–1.257	2576–2896
	Nap-Fe	3.008–5.289	0.473–1.147	2689–3035
	Nap-Ag	3.678–6.149	0.568–1.427	2736–3024
	Nap-Zn	3.789–7.899	0.564–1.139	2524–3467
pH of buffer solution; (±0.2); ()	Naproxen	3.934–4.567	0.836–0.956	2890–3205
	Nap-Cu	4.003–4.678	0.845–0.899	2600–3765
	Nap-Co	3.612–4.568	0.786–0.876	2535–3402
	Nap-Fe	3.613–4.257	0.823–0.956	2546–3867
	Nap-Ag	3.583–4.945	0.726–0.915	2394–3957
	Nap-Zn	3.993–4.456	0.736–0.925	2356–2895
Detector; wave length; (±3 nm); ()	Naproxen	4.346–4.467	0.823–0.913	2536–3406
	Nap-Cu	4.456–4.789	0.823–0.834	2675–3177
	Nap-Co	4.345–4.456	0.864–0.900	2465–2794
	Nap-Fe	4.412–4.467	0.789–0.822	2575–2904
	Nap-Ag	4.367–4.467	0.844–0.878	2356–3602
	Nap-Zn	4.367–4.419	0.812–0.901	2531–3387
Temperature; (±10°C); ()	Naproxen	4.324–4.456	0.823–8.678	2567–2958
	Nap-Cu	4.326–4.567	0.746–8.134	2296–3042
	Nap-Co	4.324–4.467	0.783–0.899	2515–3657
	Nap-Fe	4.389–4.498	0.823–0.843	2549–3208
	Nap-Ag	4.358–4.418	0.823–0.845	2285–3647
	Nap-Zn	4.329–4.475	0.813–0.843	2576–3102