Biotinylation of Deoxyguanosine at the Abasic Site in Double-Stranded Oligodeoxynucleotides

Figure 1

Biotinylation of deoxyguanosine at an abasic site in double-stranded DNA oligonucleotides. The biotinylation of the unpaired deoxyguanosine is achieved by copper-catalyzed click reaction after the conjugation of the oligodeoxynucleotide with 2-oxohex-5-ynal (1).