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Journal of Analytical Methods in Chemistry
Volume 2016 (2016), Article ID 5093537, 9 pages
http://dx.doi.org/10.1155/2016/5093537
Research Article

Comparative Pharmacokinetics and Bioavailability of Epimedin C in Rat after Intramuscular Administration of Epimedin C, a Combination of Four Flavonoid Glycosides and Purified Herba Epimedii Extract

1ImVin Pharmaceutical Co., Ltd., 2 Fangcaodian Road, Guangzhou 510663, China
2Guangdong Provincial Hospital of Chinese Medicine, 111 Dade Road, Guangzhou 510120, China

Received 23 February 2016; Revised 13 June 2016; Accepted 13 June 2016

Academic Editor: Mohamed Abdel-Rehim

Copyright © 2016 Shunjun Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Chuan-Ke-Zhi (CKZ), a purified Herba Epimedii extract, is a potent Chinese medicine preparation whose main bioactive components are a class of flavonoid glycosides such as epimedins A, B, and C and icariin. And epimedin C is far more abundant than other flavones in this extract. This study aims to investigate the pharmacokinetic and bioavailability of epimedin C and what effects, if any, other ingredients in CKZ have on its pharmacokinetics. Epimedin C, CKZ, and a combination of epimedins A, B, and C and icariin were, respectively, administrated to rats, and then the pharmacokinetic parameters of epimedin C in the three groups were calculated and compared. The result indicated that , , and of epimedin C were significantly different among the three groups (), and compared with the epimedin C group, the absorption of epimedin C significantly increased in the CKZ group. Furthermore, in this study the absolute bioavailability of epimedin C was also investigated by comparing intramuscular and intravenous administration of epimedin C. As a result, epimedin C could be quickly absorbed with extremely high absolute bioavailability after intramuscular administration.