Comparative Pharmacokinetics and Bioavailability of Epimedin C in Rat after Intramuscular Administration of Epimedin C, a Combination of Four Flavonoid Glycosides and Purified Herba Epimedii Extract

Table 3

The pharmacokinetic parameters of epimedin C after intramuscular administration of epimedin C, combination of four flavonoid glycosides, and CKZ at the epimedin C dose of 0.33 mg/kg ().

Parameters	Intramuscular administration			Intravenous administration	Bioavailability
	CKZ	Combination	Epimedin C	Epimedin C	(%)
(h)	0.47 0.08	0.39 0.05	0.33 0.14	0.32 0.07
(µg/L)	468.13 135.83	419.83 225.30	515.48 162.72	696.81 83.69
(L/kg)	0.53 0.13	0.65 0.23	0.59 0.25	0.62 0.12
(L/h/kg)	0.79 0.19	1.15 0.39	1.26 0.21	1.35 0.16
MRT (h)	0.77 0.15	0.69 0.06	0.52 0.12	0.25 0.04
AUC (µg/L⋅h)	448.45 137.74	326.59 139.081	271.03 44.39	246.45 27.49	109.97

Data versus those of intramuscular administration of epimedin C, ; .
= []/[] 100%.