Determination of Levetiracetam in Human Plasma by Dispersive Liquid-Liquid Microextraction Followed by Gas Chromatography-Mass Spectrometry

Table 2

DLLME parameters.

Optimized parameters		Defined conditions
Dispersing solvent types	Methanol, isopropyl alcohol, acetonitrile, and acetone	Isopropyl alcohol
Extraction solvent types	Chloroform, dichloromethane, carbon tetrachloride, and tetrachloroethylene	Chloroform
Dispersing solvent volumes (µL)	200, 300, 350, 400, and 500	400
Extraction solvent volumes (µL)	50, 90, 130, and 170	130
NaCl concentration (%)	0–10	0
Type of shaking (seconds)	0–30	0