Determination of Levetiracetam in Human Plasma by Dispersive Liquid-Liquid Microextraction Followed by Gas Chromatography-Mass Spectrometry

Table 3

Linearity and limit of quantification of the LEV method for analyses of human plasma.

Parameters	LEV
Slope	0.0040
Intercept	0.0011
Regression coefficient ()	0.9988
Linear range (µg mL^−1)	2–80
Experimental value	1.15
value	0.37
LLOQ (µg mL^−1)	2
Precision (RSD, %)	5.8
Accuracy (RE, %)	0.7

Calibration curves were prepared in quadruplicate () for concentrations of 2, 4, 10, 20, 40, 60, and 80 µg mL⁻¹; , where is the ratio between the analyte peak area and the IS peak area; is the slope, is the intercept, and is the concentration of the measured solution in µg mL⁻¹; experimental .