The Effect of Salt-Processed Psoralea corylifolia on Generative Organ Targeting

Table 3

Stability of psoralen and isopsoralen in rat tissues. ( for sexual organs; for other tissues).

Compound	Tissues	Spiked concentrations	Freeze-thaw stability		Short-term stability		Long-term stability
		(ng/mL)	Mean ± SD	RE (%)	Mean ± SD	RE (%)	Mean ± SD	RE (%)
Psoralen	Heart	6.945	6.80 ± 0.11	−2.16	6.76 ± 0.21	−2.73	6.82 ± 0.14	−1.83
		69.45	68.23 ± 0.91	−1.76	67.11 ± 2.25	−3.38	70.42 ± 1.17	1.40
		1111.2	1062.25 ± 83.85	−4.41	1051.78 ± 23.11	−5.35	1131.52 ± 10.56	1.83
	Liver	6.945	7.07 ± 0.37	1.82	7.12 ± 0.08	2.59	7.10 ± 0.04	2.25
		69.45	74.10 ± 1.39	6.69	71.58 ± 2.71	3.06	70.66 ± 1.09	1.74
		1111.2	1052.56 ± 54.21	−5.28	1150.08 ± 44.05	3.50	1097.14 ± 65.50	−1.27
	Spleen	6.945	6.91 ± 0.13	−0.49	6.83 ± 0.14	−1.71	7.07 ± 0.06	1.80
		69.45	68.54 ± 0.22	−1.30	67.94 ± 2.24	−2.15	67.60 ± 0.31	−2.66
		1111.2	1049.60 ± 16.07	−5.54	1130.31 ± 54.07	1.72	1114.40 ± 70.06	0.29
	Lung	6.945	7.16 ± 0.12	3.05	7.40 ± 0.10	−5.27	7.34 ± 0.30	5.75
		69.45	73.80 ± 0.02	6.27	66.44 ± 0.98	−4.34	74.02 ± 1.78	6.59
		1111.2	1008.84 ± 53.80	−9.21	651.02 ± 7.32	−41.41	915.37 ± 75.71	−17.62
	Kidney	6.945	6.66 ± 0.32	−4.04	6.97 ± 0.12	0.38	6.84 ± 0.02	−1.48
		69.45	70.30 ± 1.11	1.23	69.25 ± 2.06	−0.30	70.24 ± 0.41	1.14
		1111.2	1038.70 ± 18.58	−6.52	1082.02 ± 48.19	−2.63	1109.80 ± 78.26	−1.26
	Ovary	6.945	6.88 ± 0.18	−0.96	6.96 ± 0.05	0.17	7.04 ± 0.11	1.39
		69.45	69.25 ± 2.59	−0.29	69.66 ± 1.22	0.30	70.11 ± 0.74	0.96
		1111.2	1038.33 ± 17.84	−6.56	1130.92 ± 32.55	1.77	1099.28 ± 43.85	−1.07
	Testis	6.945	6.87 ± 0.20	−1.12	6.48 ± 0.11	−6.71	6.78 ± 0.17	−2.31
		69.45	68.19 ± 0.18	−1.82	69.82 ± 1.90	0.53	70.77 ± 7.55	1.90
		1111.2	1077.27 ± 79.52	−3.05	1086.87 ± 41.36	−2.19	1050.69 ± 77.20	−5.45
Isopsoralen	Heart	7.62	7.53 ± 0.26	−1.23	7.26 ± 0.09	−4.69	7.46 ± 0.17	−2.16
		76.2	77.58 ± 0.85	1.81	75.01 ± 1.42	−1.56	75.79 ± 0.81	−0.54
		1219.2	1108.20 ± 75.09	−9.10	1166.75 ± 67.08	−4.30	1284.62 ± 15.80	5.37
	Liver	7.62	7.08 ± 0.05	−5.17	7.38 ± 0.10	−3.24	7.20 ± 0.07	−4.60
		76.2	72.31 ± 0.24	−5.11	76.49 ± 1.17	0.38	71.92 ± 0.85	−5.61
		1219.2	1126.26 ± 25.38	−5.83	1154.34 ± 45.06	−5.32	1120.07 ± 48.38	−8.13
	Spleen	7.62	7.75 ± 0.12	1.73	7.66 ± 0.11	0.56	7.58 ± 0.10	−0.59
		76.2	76.86 ± 0.98	0.86	76.88 ± 0.63	0.90	78.33 ± 1.21	2.79
		1219.2	1140.32 ± 55.99	−6.47	1100.51 ± 67.67	−9.73	1143.83 ± 87.36	−6.18
	Lung	7.62	7.51 ± 0.39	−1.46	7.54 ± 0.09	−1.03	7.24 ± 0.21	−4.95
		76.2	79.23 ± 1.79	3.98	81.08 ± 0.93	0.06	79.02 ± 3.35	3.70
		1219.2	1187.77 ± 56.03	−2.58	1135.93 ± 38.04	−7.01	1163.82 ± 76.16	−5.38
	Kidney	7.62	7.62 ± 0.05	−0.02	7.61 ± 0.24	−0.13	7.40 ± 0.35	−2.85
		76.2	76.28 ± 1.53	0.11	74.53 ± 4.50	−2.19	76.85 ± 0.14	0.85
		1219.2	1111.45 ± 55.37	−4.66	1185.88 ± 96.40	−2.73	1231.28 ± 71.66	0.99
	Ovary	7.62	7.55 ± 0.11	−0.87	7.57 ± 0.28	−0.68	7.67 ± 0.19	0.67
		76.2	77.38 ± 0.89	1.55	76.55 ± 1.16	0.46	77.47 ± 1.03	1.67
		1219.2	1164.91 ± 55.17	−4.45	1250.56 ± 29.56	2.57	1227.01 ± 41.73	0.64
	Testis	7.62	7.77 ± 0.27	1.92	7.32 ± 0.33	−3.95	7.51 ± 0.32	−1.44
		76.2	76.07 ± 1.85	−0.18	76.80 ± 1.56	0.85	76.17 ± 3.56	−0.04
		1219.2	1241.11 ± 20.93	3.95	1180.85 ± 11.49	−4.15	1104.70 ± 68.05	−7.59