Metabolite Profiling, Pharmacokinetics, and In Vitro Glucuronidation of Icaritin in Rats by Ultra-Performance Liquid Chromatography Coupled with Mass Spectrometry

Table 3

Kinetic parameters of icaritin glucuronidation by RLM and RIM (mean ± SD).

Protein source	Metabolite	(nmol/min/mg)	(μM)	(μM)	(mL/min/mg)	Model
RLM	M13					SI
	M18					SI
RIM	M13			N.A.		MM
	M18			N.A.		MM

Note. SI, substrate inhibition model; MM, Michaelis-Menten model; N.A., not available.