Development and Validation of a Chromatography Method Using Tandem UV/Charged Aerosol Detector for Simultaneous Determination of Amlodipine Besylate and Olmesartan Medoxomil: Application to Drug-Excipient Compatibility Study

Table 1

Linear and polynomial fit equations for calibration curves for AMLO and OLME determined by HPLC-DAD and HPLC-CAD.

	Range (μg mL^−1)	Equation	R^2	LOD (μg mL^−1)	LOQ (μg mL^−1)
AMLO	15–250	DAD-linear	0.9953	1	4
		y = 0.5862x + 1.4772
		CAD-linear	0.0083	4	10
		y = 0.0221x − 0.0356
		CAD-polynomial	0.9994	4	10
		y = −2.10^−5x^2 + 0.0271x + 0.1454
OLME	25–500	DAD-linear	0.9958	1	10
		y = 0.6918x + 4.1201
		CAD-linear	0.9908	5	15
		y = 0.0159x − 0.817
		CAD-polynomial	0.9988	5	15
		y = −2.10^−5x^2 + 0.0257x + 0.2194