Development and Validation of a Chromatography Method Using Tandem UV/Charged Aerosol Detector for Simultaneous Determination of Amlodipine Besylate and Olmesartan Medoxomil: Application to Drug-Excipient Compatibility Study

Table 4

Recovery of AMLO and OLME after 3 and 6 months at 40°C ± 1°C under dry condition in binary and ternary mixtures.

Excipient	Binary mixtures				Ternary mixtures
	3 months		6 months		3 months		6 months
	AMLO (%)	OLME (%)	AMLO (%)	OLME (%)	AMLO (%)	OLME (%)	AMLO (%)	OLME (%)
Corn starch	102.9 ± 0.4	101.3 ± 0.5	98.2 ± 0.5	97.5 ± 0.6	99.4 ± 0.1	101.7 ± 0.6	98.0 ± 0.6	102.8 ± 0.9
	100.3 ± 0.2	101.7 ± 0.3	101.6 ± 0.6	98.7 ± 0.5	99.4 ± 0.6	100.6 ± 0.5	98.6 ± 0.9	103.6 ± 0.3
Microcrystalline cellulose	98.8 ± 0.5	98.4 ± 0.7	99.6 ± 0.5	97.5 ± 0.7	100.8 ± 0.6	102.3 ± 0.9	98.1 ± 0.8	103.7 ± 0.5
Croscarmellose sodium	109.2 ± 0.4	99.8 ± 0.3	97.9 ± 0.4	103.9 ± 0.5	101.1 ± 0.2	101.8 ± 0.6	98.9 ± 0.6	101.5 ± 0.4
Magnesium stearate	103.0 ± 0.5	98.0 ± 0.6	105.0 ± 0.7	100.9 ± 0.4	99.4 ± 0.6	99.0 ± 0.2	100.5 ± 0.4	100.9 ± 0.8
Polyvinyl alcohol	104.6 ± 0.4	98.0 ± 0.4	98.6 ± 0.5	102.5 ± 0.3	103.1 ± 0.4	100.2 ± 0.2	99.6 ± 0.3	101.9 ± 0.3
Titanium dioxide	104.3 ± 0.6	99.1 ± 0.2	101.2 ± 0.6	100.8 ± 0.6	99.8 ± 0.4	102.6 ± 0.8	99.8 ± 0.6	102.1 ± 0.7
Talc	98.0 ± 0.7	98.9 ± 0.6	98.2 ± 0.8	99.8 ± 0.8	103.7 ± 0.3	98.8 ± 0.7	99.5 ± 0.7	101.5 ± 0.6
PVP	101.1 ± 0.3	99.5 ± 0.5	100.8 ± 0.6	100.0 ± 0.5	98.5 ± 0.8	101.8 ± 0.8	101.9 ± 0.3	101.3 ± 0.9
Lactose monohydrate	100.2 ± 0.8	103.6 ± 0.9	97.9 ± 0.7	103.5 ± 0.8	98.5 ± 0.4	98.5 ± 0.2	100.5 ± 0.7	99.7 ± 0.5
PEG	99.3 ± 0.3	98.7 ± 0.4	101.4 ± 0.5	99.2 ± 0.5	102.3 ± 0.5	99.5 ± 0.2	99.3 ± 0.4	102.7 ± 0.5