Development and Validation of a Chromatography Method Using Tandem UV/Charged Aerosol Detector for Simultaneous Determination of Amlodipine Besylate and Olmesartan Medoxomil: Application to Drug-Excipient Compatibility Study

Table 5

Recovery of AMLO and OLME after 3 and 6 months at 40°C ± 1°C under 75% ± 5% relative humidity in binary and ternary mixtures.

Excipient	Binary mixtures				Ternary mixtures
	3 months		6 months		3 months		6 months
	AMLO (%)	OLME (%)	AMLO (%)	OLME (%)	AMLO (%)	OLME (%)	AMLO (%)	OLME (%)
Corn starch	99.3 ± 0.5	102.4 ± 0.4	104.3 ± 0.2	107.1 ± 0.8	101.7 ± 0.4	99.2 ± 0.9	99.2 ± 0.5	110.1 ± 0.7
	99.0 ± 0.5	100.5 ± 0.7	74.2 ± 0.4	102.5 ± 0.8	100.5 ± 0.7	98.7 ± 0.9	82.7 ± 0.9	101.5 ± 0.7
Microcrystalline cellulose	102.3 ± 0.3	100.4 ± 0.4	98.2 ± 0.4	100.8 ± 0.5	105.9 ± 0.9	98.2 ± 0.4	101.7 ± 0.2	101.2 ± 0.2
Croscarmellose sodium	99.7 ± 0.8	100.3 ± 0.5	99.8 ± 0.3	102.6 ± 0.3	103.2 ± 0.8	99.4 ± 0.6	92.3 ± 0.3	93.7 ± 0.5
Magnesium stearate	100.8 ± 0.8	101.6 ± 0.4	99.6 ± 0.6	100.4 ± 0.6	99.0 ± 0.2	99.5 ± 0.4	81.2 ± 0.7	83.1 ± 0.7
Polyvinyl alcohol	98.3 ± 0.9	98.5 ± 0.9	100.7 ± 0.8	102.9 ± 0.4	98.2 ± 0.6	100.3 ± 0.2	84.4 ± 0.6	83.6 ± 0.2
Titanium dioxide	98.1 ± 0.9	100.6 ± 0.5	98.3 ± 0.4	99.9 ± 0.5	98.4 ± 0.6	98.1 ± 0.4	101.8 ± 0.3	104.3 ± 0.4
Talc	99.9 ± 0.7	98.7 ± 0.6	104.1 ± 0.5	101.1 ± 0.3	99.4 ± 0.3	100.5 ± 0.5	84.2 ± 0.4	79.5 ± 0.6
PVP	98.1 ± 0.9	99.0 ± 0.7	98.2 ± 0.7	83.7 ± 0.9	101.3 ± 0.7	101.9 ± 0.4	75.2 ± 0.5	81.1 ± 0.9
Lactose monohydrate	100.3 ± 0.6	101.8 ± 0.6	73.7 ± 0.3	76.1 ± 0.6	98.9 ± 0.9	101.3 ± 0.8	78.3 ± 0.8	74.2 ± 0.8
PEG	99.1 ± 0.7	99.8 ± 0.5	103.1 ± 0.3	98.2 ± 0.9	99.9 ± 0.5	99.1 ± 0.6	82.4 ± 0.7	86.9 ± 0.4