Journal of Analytical Methods in Chemistry / 2017 / Article / Tab 5 / Research Article
Development and Validation of a Chromatography Method Using Tandem UV/Charged Aerosol Detector for Simultaneous Determination of Amlodipine Besylate and Olmesartan Medoxomil: Application to Drug-Excipient Compatibility Study Table 5 Recovery of AMLO and OLME after 3 and 6 months at 40°C ± 1°C under 75% ± 5% relative humidity in binary and ternary mixtures.
Excipient Binary mixtures Ternary mixtures 3 months 6 months 3 months 6 months AMLO (%) OLME (%) AMLO (%) OLME (%) AMLO (%) OLME (%) AMLO (%) OLME (%) Corn starch 99.3 ± 0.5 102.4 ± 0.4 104.3 ± 0.2 107.1 ± 0.8 101.7 ± 0.4 99.2 ± 0.9 99.2 ± 0.5 110.1 ± 0.7 99.0 ± 0.5 100.5 ± 0.7 74.2 ± 0.4 102.5 ± 0.8 100.5 ± 0.7 98.7 ± 0.9 82.7 ± 0.9 101.5 ± 0.7 Microcrystalline cellulose 102.3 ± 0.3 100.4 ± 0.4 98.2 ± 0.4 100.8 ± 0.5 105.9 ± 0.9 98.2 ± 0.4 101.7 ± 0.2 101.2 ± 0.2 Croscarmellose sodium 99.7 ± 0.8 100.3 ± 0.5 99.8 ± 0.3 102.6 ± 0.3 103.2 ± 0.8 99.4 ± 0.6 92.3 ± 0.3 93.7 ± 0.5 Magnesium stearate 100.8 ± 0.8 101.6 ± 0.4 99.6 ± 0.6 100.4 ± 0.6 99.0 ± 0.2 99.5 ± 0.4 81.2 ± 0.7 83.1 ± 0.7 Polyvinyl alcohol 98.3 ± 0.9 98.5 ± 0.9 100.7 ± 0.8 102.9 ± 0.4 98.2 ± 0.6 100.3 ± 0.2 84.4 ± 0.6 83.6 ± 0.2 Titanium dioxide 98.1 ± 0.9 100.6 ± 0.5 98.3 ± 0.4 99.9 ± 0.5 98.4 ± 0.6 98.1 ± 0.4 101.8 ± 0.3 104.3 ± 0.4 Talc 99.9 ± 0.7 98.7 ± 0.6 104.1 ± 0.5 101.1 ± 0.3 99.4 ± 0.3 100.5 ± 0.5 84.2 ± 0.4 79.5 ± 0.6 PVP 98.1 ± 0.9 99.0 ± 0.7 98.2 ± 0.7 83.7 ± 0.9 101.3 ± 0.7 101.9 ± 0.4 75.2 ± 0.5 81.1 ± 0.9 Lactose monohydrate 100.3 ± 0.6 101.8 ± 0.6 73.7 ± 0.3 76.1 ± 0.6 98.9 ± 0.9 101.3 ± 0.8 78.3 ± 0.8 74.2 ± 0.8 PEG 99.1 ± 0.7 99.8 ± 0.5 103.1 ± 0.3 98.2 ± 0.9 99.9 ± 0.5 99.1 ± 0.6 82.4 ± 0.7 86.9 ± 0.4