Research Article
Supercritical Fluid Chromatography of Drugs: Parallel Factor Analysis for Column Testing in a Wide Range of Operational Conditions
Table 1
Design of Experiment (DoE) based on Brereton’s method.
| | | | | Codes | | (°C) | (bar) | (MeOH%/min) |
| | 35 (0) | 175 (0) | 5.00 (0) | 000 | | 53 (+1) | 129 (−1) | 3.12 (−1) | +−− | | 53 (+1) | 220 (+1) | 6.83 (+1) | +++ | | 16 (−1) | 220 (+1) | 3.12 (−1) | −+− | | 16 (−1) | 129 (−1) | 6.83 (+1) | −−+ | | 35 (0) | 175 (0) | 5.00 (0) | 000 | | 35 (0) | 175 (0) | 5.00 (0) | 000 | | 53 (+1) | 220 (+1) | 3.12 (−1) | ++− | | 16 (−1) | 220 (+1) | 6.83 (+1) | −++ | | 53 (+1) | 129 (−1) | 6.83 (+1) | +−+ | | 16 (−1) | 129 (−1) | 3.12 (−1) | −−− | | 35 (0) | 175 (0) | 5.00 (0) | 000 |
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