A Liquid Chromatography-Tandem Mass Spectrometry Method for Evaluation of Two Brands of Enalapril 20 mg Tablets in Healthy Human Volunteers

Table 6

Pharmacokinetic parameters of healthy human volunteers with the test and reference formula ().

Calibration curve number	Enalapril 20 mg		Enalaprilat
	Reference formulae (A)	Test formulae (B)	Reference formulae (A)	Test formulae (B)
(ng/ml)
(h)
(ng·h/ml)
(ng·h/ml)
el ()
(h)
Relative bioavailability (%) (B/A)	94.417

: maximum plasma concentration, : time required to achieve maximum concentration, : area under the plasma concentration-time curve from time zero to 72 h, : area under the plasma concentration-time curve from time zero to infinity, Kel: elimination rate constant, and : elimination half- life.