Research Article
Comparative Liquid Chromatographic Study for Concurrent Determination of Canagliflozin and Metformin in Combined Tablets
Table 3
Determination of CANA and MET in lab prepared mixtures by the proposed methods.
| Mix. number | CANA | MET | CANA | MET | Taken (µg/mL) | Found (µg/mL) | % recovery | Found (µg/mL) | % recovery |
| HPLC method | 1 | 8 | 70 | 8.03 | 100.45 | 69.74 | 99.63 | 2 | 10 | 65 | 10.16 | 101.75 | 64.38 | 99.05 | 3 | 20 | 80 | 19.81 | 98.99 | 79.51 | 99.39 | 4 | 25 | 65 | 24.88 | 99.53 | 65.27 | 100.42 | | 3 | 60 | 2.94 | 98.09 | 59.71 | 99.51 |
| | Mean ± SD | | |
| UPLC method | 1 | 8 | 70 | 7.94 | 99.21 | 70.20 | 100.29 | 2 | 10 | 65 | 9.92 | 99.17 | 65.58 | 100.89 | 3 | 20 | 80 | 19.85 | 99.23 | 78.64 | 98.29 | 4 | 25 | 65 | 24.75 | 99.01 | 65.42 | 100.64 | | 3 | 60 | 3.01 | 100.19 | 59.69 | 99.48 |
| | Mean ± SD | | |
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mixture represents the CANA: MET ratio as as in dosage form.
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