Comparative Liquid Chromatographic Study for Concurrent Determination of Canagliflozin and Metformin in Combined Tablets

Table 4

Assay of canagliflozin and metformin in Invokamet tablets and application of the standard addition technique.

	HPLC										UPLC
Pharmaceutical formulation	CANA					MET					CANA					MET
	Claimed g·mL^−1	% found	Standard addition			Claimed g·mL^−1	% found	Standard addition			Claimed µg·mL^−1	% found	Standard addition			Claimed µg·mL^−1	% found	Standard addition
			Pure added	Pure found	% recovery			Pure added	Pure found	% recovery			Pure added	Pure found	% recovery			Pure added	Pure found	% recovery
Invokamet; 50 CANA/1000 MET	3 g·mL^−1	100.46	7	6.96	99.56	60 g·mL^−1	100.15	5	4.95	99.09	3 g·mL^−1	99.46	7	7.09	101.38	60 µg·mL^−1	98.86	5	5.01	100.22
			22	21.81	99.16			5	5.11	101.94			22	21.59	98.12			5	4.86	97.25
			17	16.96	99.82			20	19.99	99.93			17	16.93	99.58			20	19.84	99.19
			5	4.99	99.87			10	10.06	100.57			5	5.02	100.49			10	9.97	99.72
			Mean ± SD		99.60 ± 0.33			Mean ± SD		100.38 ± 1.20			Mean ± SD		99.89 ± 1.39			Mean ± SD	99.09 ± 1.31