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Journal of Analytical Methods in Chemistry
Volume 2017 (2017), Article ID 9206297, 7 pages
https://doi.org/10.1155/2017/9206297
Research Article

Application of 19F NMR Spectroscopy for Content Determination of Fluorinated Pharmaceuticals

1Department of Pharmaceutical Chemistry, University of Nairobi, P.O. Box 19676-00202, Nairobi, Kenya
2Chemisches und Veterinäruntersuchungsamt (CVUA) Karlsruhe, Weissenburger Strasse 3, 76187 Karlsruhe, Germany

Correspondence should be addressed to Dirk W. Lachenmeier

Received 31 May 2017; Revised 22 August 2017; Accepted 6 September 2017; Published 18 October 2017

Academic Editor: Josep Esteve-Romero

Copyright © 2017 Alex O. Okaru et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A simple, rapid, and selective quantitative nuclear magnetic resonance spectroscopic method was evaluated for the determination of the content of fluorinated pharmaceuticals. 19F NMR spectra were either obtained in dimethylsulfoxide-d6 or aqueous buffer, using trifluoroacetic acid as internal standard. Quantification of 13 fluorine-containing pharmaceuticals spanning various pharmacological classes was accomplished using the proposed method. The method was found to be fit for purpose (interday precision 1.2% relative standard deviation) and may thus be applied for routine analysis and quality control of fluorine-containing pharmaceuticals due to its simplicity, nondestructive sample measurement, reliability, and high specificity. Therefore, 19F NMR may serve as a suitable analytical tool for the identification and selective determination of fluorinated pharmaceuticals used as reference materials and bulk samples.