Research Article
A Standardized Approach to Quantitative Analysis of Nicotine in e-Liquids Based on Peak Purity Criteria Using High-Performance Liquid Chromatography
Table 4
Stressed conditions for e-liquid assay samples, placebos, and blanks.
| | Sample stress type | Time | Assay sample (mL) | Water (mL) | 0.1 N·HCl (mL) | 1 N·NaOH (mL) | H2O2 (6%) (mL) |
| | Control | N/A | 4.5 | 0.5 | 0 | 0 | 0 | | Acid hydrolysis | 30 min | 4.5 | 0 | 0.5 | 0 | 0 | | Base hydrolysis | 30 min | 4.5 | 0 | 0 | 0.5 | 0 | | Oxidation | 30 min | 4.5 | 0 | 0 | 0 | 0.5 | | Thermal | 2 hrs | 4.5 | 0.5 | 0 | 0 | 0 |
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