A Standardized Approach to Quantitative Analysis of Nicotine in e-Liquids Based on Peak Purity Criteria Using High-Performance Liquid Chromatography

Table 6

Results of forced degradation of various e-liquid flavors.

Name of sample	Category	Stressed condition
		% control assay	% acid degradation	% base degradation	% oxidation degradation
Standard	NA	NA	7.75	8.29	7.62
QC	NA	99.39	ND	ND	3.5
e-Liquid flavor P	Sweet	95.98	ND	ND	12.2
e-Liquid flavor Q	Menthol	100.76	1.53	ND	4.14
e-Liquid flavor R	Tobacco	103.09	4.69	5.68	7.53
e-Liquid flavor S	Menthol	100.14	2.04	3.38	10.28
e-Liquid flavor T	Fruit	96.18	1.03	ND	2.06
e-Liquid flavor U	Coffee	97.68	ND	1.59	4.33
e-Liquid flavor A	Tobacco	96.19	1.94	1.00	4.75
e-Liquid flavor C	Vanilla	97.31	1.38	0.69	4.44
e-Liquid flavor E	Fruit	98.13	ND	1.44	14.13
e-Liquid flavor G	Fruit	96.94	6.38	1.00	2.5

Note. % degradation of ±1% is considered as no degradation (ND).