A Stability Indicating HPLC Assay Method for Analysis of Rivastigmine Hydrogen Tartrate in Dual-Ligand Nanoparticle Formulation Matrices and Cell Transport Medium

Figure 2

HPLC chromatogram of RHT under various stress conditions conducted at 37°C for 48 hours. (a) Acid degradation, (b) alkali degradation, (c) hydrolysis, and (d) oxidation. Analysis of RHT was not interfered by the degradation products (∗). Peak purity reports are shown in the insets, confirming that the RHT peaks are pure and the purity factors are within the calculated threshold limit.

(a)

(b)

(c)

(d)