A Stability Indicating HPLC Assay Method for Analysis of Rivastigmine Hydrogen Tartrate in Dual-Ligand Nanoparticle Formulation Matrices and Cell Transport Medium

Table 2

Summary of findings in RHT-forced degradation studies.

Forced degradation condition	Temp. (°C)	Incubation duration (hrs)	Remaining percentage
Acid hydrolysis: RHT in 2 N HCl	60	48	87.4
	37	48	97.8
Base hydrolysis: RHT in 0.5 N NaOH	60	2	80.9
	60	48	0.0
	37	48	29.7
Hydrolysis: RHT in water	60	48	99.2
	37	48	99.7
Oxidation: RHT in 30% (w/v) H2O2	60	48	0.0
	37	48	79.6