Screening and Characterizing Tyrosinase Inhibitors from Salvia miltiorrhiza and Carthamus tinctorius by Spectrum-Effect Relationship Analysis and Molecular Docking

Table 4

Inhibition effect of protocatechuic aldehyde, tanshinone IIA, hydroxysafflor yellow A, lithospermic acid, and salvianolic acid A on tyrosinase ().

Compounds	Concentration (mmol)	Inhibition rate (%)
Blank	PBS (50 mM, pH 6.8)	0.44 ± 0.02
Kojic acid	1.6	88.93 ± 0.28
	0.8	85.97 ± 0.45
	0.4	76.63 ± 1.02
	0.2	63.97 ± 2.11
	0.1	40.72 ± 0.15
Protocatechuic aldehyde	1.6	80.18 ± 0.08
	0.8	69.91 ± 2.97
	0.4	49.80 ± 1.30
	0.2	21.29 ± 1.01
	0.1	13.78 ± 0.95
Tanshinone IIA	1.6	57.88 ± 1.98
	0.8	37.26 ± 2.87
	0.4	18.23 ± 2.23
	0.2	6.03 ± 1.12
	0.1	1.98 ± 0.05
Hydroxysafflor yellow A	1.6	62.48 ± 1.34
	0.8	60.22 ± 2.28
	0.4	55.85 ± 1.80
	0.2	39.23 ± 1.12
	0.1	14.58 ± 0.55
Lithospermic acid	1.6	26.09 ± 3.28
	0.8	19.62 ± 2.22
	0.4	11.52 ± 2.64
	0.2	7.28 ± 1.01
	0.1	4.32 ± 0.21
Salvianolic acid A	1.6	17.74 ± 3.06
	0.8	14.42 ± 1.14
	0.4	8.25 ± 1.98
	0.2	5.04 ± 0.91
	0.1	1.25 ± 1.32