LC-MS/MS Method for Simultaneous Quantification of Dexmedetomidine, Dezocine, and Midazolam in Rat Plasma and Its Application to Their Pharmacokinetic Study

Figure 2

SRM chromatograms of dexmedetomidine (I), dezocine (II), midazolam (III), and IS in rat plasma. (a) Chromatographic profile of blank rat plasma; (b) chromatographic profile of rat plasma spiked with dexmedetomidine (I, 0.1 ng/mL), dezocine (II, 0.1 ng/mL), midazolam (III, 0.2 ng/mL), and IS; (c) chromatographic profile of a plasma sample 1 h after administration of the analytes to a rat.

(a)

(b)

(c)