LC-MS/MS Method for Simultaneous Quantification of Dexmedetomidine, Dezocine, and Midazolam in Rat Plasma and Its Application to Their Pharmacokinetic Study

Table 2

Linear ranges, correlation coefficients, weight factors, regression equations, and LLOQs for all analytes in rat plasma.

Analytes	Linear ranges (ng/mL)	r^2	Weight factors	Regression equations	LLOQs (ng/mL)
Dexmedetomidine	0.1–100	0.9975	1/X^2	Y = 4.52 × 10^−5 + 4.99 × 10^−3X	0.1
Dezocine	0.1–100	0.9962	1/X^2	Y = 2.33 × 10^−5 + 1.19 × 10^−3X	0.1
Midazolam	0.2–200	0.9988	1/X^2	Y = −5.23 × 10^−6 + 1.91 × 10^−3X	0.2