LC-MS/MS Method for Simultaneous Quantification of Dexmedetomidine, Dezocine, and Midazolam in Rat Plasma and Its Application to Their Pharmacokinetic Study

Table 6

Pharmacokinetic (PK) parameters of dexmedetomidine (20 μg/kg), dezocine (80 μg/kg), and midazolam (400 μg/kg) following single intravenous administration in SD rats (mean ± SD, ).

PK parameters	Unit	Dexmedetomidine	Dezocine	Midazolam
AUC(0–8 h)	ng/mL·min	1336.05 ± 298.0	2317.92 ± 442.3	26,330.36 ± 6085.2
MRT(0–8 h)	min	131.49 ± 10.4	171.60 ± 13.6	89.42 ± 2.8
T1/2z	min	141.25 ± 61.4	225.39 ± 70.2	80.51 ± 19.3
C2 min	ng/mL	23.24 ± 5.0	22.37 ± 6.6	645.68 ± 157.5
Vd	L/kg	2.68 ± 0.6	8.75 ± 2.2	1.778 ± 0.4
CLz/F	L/min/kg	0.014 ± 0.004	0.028 ± 0.007	0.016 ± 0.004

AUC, area under the curve; MRT, mean residence time; T_1/2z, half-life; C_2 min, the concentration at 2 min; V_d, apparent volume of distribution; C_Lz/F, clearance.