Table of Contents Author Guidelines Submit a Manuscript
Journal of Analytical Methods in Chemistry
Volume 2018, Article ID 3631249, 7 pages
Research Article

“Turn-Off” Fluorescent Sensor for Pamidronate Disodium and Zoledronic Acid Based on Newly Synthesized Carbon Dots from Black Tea

1The Graduate School, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin 300071, China
2Department of Orthopedic Oncology, Tianjin Hospital, 406 Jiefang South Road, Tianjin 300210, China

Correspondence should be addressed to Yongcheng Hu; moc.621@uhgnehcgnoy

Received 9 December 2017; Revised 29 January 2018; Accepted 6 February 2018; Published 13 March 2018

Academic Editor: Chih-Ching Huang

Copyright © 2018 Peng Li and Yongcheng Hu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


As common bisphosphonates drugs, pamidronate disodium and zoledronic acid have been widely investigated for bone metastases. In this paper, a new “turn-off” model based on carbon dots (CDs) from black tea was established to analyze the two kinds of bisphosphonate drugs, pamidronate disodium and zoledronic acid. Through the new sensor, both of drugs can be quantitative, respectively, with the limit of detection of 5 × 10−9 mol·L−1 and 6 × 10−9 mol·L−1. In addition, the fluorescence of newly prepared CDs can be quenched by two drugs with various degrees via photoinduced electron transfer, which can be perfectly used to distinguish them. Most importantly, this turn-off method has been employed to analyze the two drugs under the influence of foreign interference factors. This method provides a new view and guidance for the rapid analysis and recognition of drugs for bone metastases in vitro and in vivo.