Research Article
A Robust Static Headspace GC-FID Method to Detect and Quantify Formaldehyde Impurity in Pharmaceutical Excipients
Table 3
Accuracy, intraday, and interday precision of the developed method.
| Formaldehyde spiked (µg/g) | PVP K-30 | PEG 400 | Mean recovery % (n = 3) | Intraday precision (RSD%) (n = 3) | Interday precision (RSD%) (n = 6) | Mean recovery % (n = 3) | Intraday precision (RSD%) (n = 3) | Interday precision (RSD%) (n = 6) |
| 10.0 | 104.27 | 2.65 | 1.92 | 87.76 | 0.75 | 3.18 | 50.04 | 98.14 | 1.48 | 1.56 | 89.79 | 1.59 | 3.24 | 500.4 | 98.99 | 2.96 | 3.61 | 97.70 | 2.04 | 2.67 | 1000.9 | 97.89 | 1.52 | 1.56 | 101.12 | 2.07 | 2.05 |
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