Research Article
Investigation of Interactions between Thrombin and Ten Phenolic Compounds by Affinity Capillary Electrophoresis and Molecular Docking
Table 1
Interactions of ten investigated compounds with thrombin evaluated by ACE.
| Compounds | Molecule weight | pKa | Detection wavelength (nm) | Regression equation of and | Binding constant (mL/U) |
| p-Hydroxybenzoic acid | 138.12 | 4.57 ± 0.10 | 250 | — | — | Protocatechuic acid | 154.12 | 4.45 ± 0.10 | 250 | — | — | Vanillic acid | 168.15 | 4.45 ± 0.10 | 250 | — | — | Gallic acid | 170.12 | 4.33 ± 0.10 | 250 | y = −0.184x + 0.105 (R2 = 0.95) | 0.184 | Naringenin | 272.25 | 7.52 ± 0.40 | 280 | y = −0.238x + 0.117 (R2 = 0.99) | 0.238 | Apigenin | 270.24 | 6.53 ± 0.40 | 280 | y = −0.302x + 0.147 (R2 = 0.99) | 0.302 | Baicalein | 270.24 | 6.31 ± 0.40 | 280 | y = −0.508x + 0.093 (R2 = 0.94) | 0.508 | Catechin | 290.27 | 9.54 ± 0.10 | 280 | y = −0.353x + 0.080 (R2 = 0.98) | 0.353 | Epicatechin | 290.27 | 9.54 ± 0.10 | 280 | y = −0.297x + 0.043 (R2 = 0.99) | 0.297 | Dihydroquercetin | 304.25 | 7.39 ± 0.60 | 250 | y = −0.389x + 0.075 (R2 = 0.99) | 0.389 |
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