Pharmacokinetics of Eight Flavonoids in Rats Assayed by UPLC-MS/MS after Oral Administration of Drynariae rhizoma Extract

Table 4

Extraction recovery and matrix effect of eight analytes (mean ± SD, ).

Analytes	Concentration spiked (ng/mL)	Concentration measured (ng/mL)	Extraction recovery (%)		Matrix effect (%)
			Mean (%)	RSD (%)	Mean (%)	RSD (%)
Neoeriocitrin	40.4	36.64 ± 1.34	90.78 ± 0.99	2.70	90.59 ± 1.69	4.61
	202	173.87 ± 8.38	84.22 ± 7.95	4.54	82.96 ± 8.80	5.10
	2020	1817.87 ± 60.05	91.00 ± 50.84	2.77	88.98 ± 69.26	3.85
Luteolin-7-O-β-D-glucoside	5.04	4.26 ± 0.43	82.90 ± 0.54	13.03	86.08 ± 0.31	7.08
	50.4	46.59 ± 1.09	91.26 ± 1.47	3.20	93.62 ± 0.71	1.50
	504	474.61 ± 7.57	93.81 ± 6.30	1.33	94.52 ± 8.83	1.85
Astragalin	5.1	4.22 ± 0.36	80.29 ± 0.29	6.99	85.13 ± 0.44	10.13
	102	86.14 ± 8.85	84.96 ± 11.27	13.01	83.94 ± 6.43	7.51
	1020	820.66 ± 46.2	80.23 ± 54.57	6.67	80.68 ± 37.82	4.60
Naringin	10.2	9.31 ± 0.81	94.85 ± 0.75	7.83	87.73 ± 0.86	9.59
	408	388.71 ± 8.55	95.80 ± 7.54	1.93	96.63 ± 9.64	2.47
	6120	5908.53 ± 118.32	98.51 ± 118.35	2.00	98.05 ± 118.30	2.01
Eriodictyol	1.02	0.86 ± 0.07	82.54 ± 0.06	6.87	81.43 ± 0.08	8.93
	40.8	39.4 ± 1.92	98.99 ± 2.27	5.70	97.02 ± 1.57	4.03
	816	787.55 ± 25.85	93.34 ± 27.70	3.53	94.17 ± 24.00	3.03
Luteolin	10.1	8.66 ± 0.49	86.12 ± 0.54	6.20	85.30 ± 0.44	5.09
	40.4	39.41 ± 4.73	97.24 ± 4.65	11.85	97.87 ± 4.80	12.15
	1010	894.08 ± 71.2	89.43 ± 63.90	7.07	87.62 ± 78.49	8.87
Naringenin	5.2	4.27 ± 0.45	81.60 ± 0.52	12.19	82.76 ± 0.38	8.75
	41.6	38.22 ± 1.63	90.02 ± 2.55	6.82	93.74 ± 0.70	1.80
	208	181.76 ± 9.38	85.73 ± 9.89	5.54	89.03 ± 8.86	4.79
Kaempferol	1.06	0.92 ± 0.11	93.71 ± 0.09	9.54	80.50 ± 0.13	14.65
	42.4	38.78 ± 1.93	91.05 ± 2.26	5.84	91.87 ± 1.60	4.10
	424	374.04 ± 12.54	88.47 ± 10.87	2.90	87.96 ± 14.20	3.81