Pharmacokinetics of Eight Flavonoids in Rats Assayed by UPLC-MS/MS after Oral Administration of Drynariae rhizoma Extract

Table 6

Pharmacokinetic parameters of eight analytes in rat plasma after oral administration of DRE (mean ± SD, n=6).

Analytes	AUC (0–t) (ng·h/ml)	AUC (0–∞) (ng·h/ml)	Tmax (h)	T1/2 (h)	Cmax (ng/kg)	MRT (0–t) (h)
Neoeriocitrin	3327.71 ± 238.61	3340.34 ± 237.36	0.33	1.69 ± 0.28	1490.98 ± 124.54	2.16 ± 0.15
Luteolin-7-O-β-D-glucoside	550.97 ± 44.68	565.98 ± 56.06	1	2.34 ± 0.61	440.37 ± 52.16	2.55 ± 0.28
Astragalin	1999.53 ± 338.21	2012.24 ± 331.76	0.67	1.94 ± 0.6	1203.63 ± 90.89	1.97 ± 0.25
Naringin	8669.19 ± 321.61	8760.77 ± 347.83	1	2.51 ± 0.94	4414.18 ± 360.38	2.36 ± 0.08
Eriodictyol	894.09 ± 33.5	929.83 ± 26.85	0.67	2.49 ± 0.19	232.76 ± 8.52	3.24 ± 0.14
Luteolin	2040.99 ± 219.28	2144.07 ± 173.66	1	2.62 ± 0.64	895.98 ± 140.34	3.51 ± 0.11
Naringenin	946.98 ± 49.06	1164.21 ± 58.65	6	3.21 ± 0.54	153.87 ± 17.39	6.89 ± 0.04
Kaempferol	232.81 ± 29.32	244.43 ± 34.91	1	2.86 ± 0.58	102.82 ± 11.61	2.84 ± 0.32