Development of an Ultra-High Performance Liquid Chromatography Method for Simultaneous Determination of Six Active Compounds in Fructus aurantii and Rat Plasma and Its Application to a Comparative Pharmacokinetic Study in Rats Administered with Different Doses

Table 2

Regression equations, correlation coefficients, linear ranges, LOD, and LLOQ of meranzin hydrate, naringenin, and hesperetin in rat plasma.

Components	Linear regression equation	Correlation coefficient ()	Linear range (ng/mL)	LOD (ng/mL)	LLOQ (ng/mL)
Meranzin hydrate	y = 63.086x − 0.9615	0.9989	3.3–3300	0.498	3.30
Naringenin	y = 210.36x + 8.3364	0.9981	6.95–3555	1.082	6.95
Hesperetin	y = 29.540x + 3.5492	0.9956	1.8–236	0.211	1.80

y: peak area of the components; x: concentration in ng/mL.