Development of an Ultra-High Performance Liquid Chromatography Method for Simultaneous Determination of Six Active Compounds in Fructus aurantii and Rat Plasma and Its Application to a Comparative Pharmacokinetic Study in Rats Administered with Different Doses

Table 5

Pharmacokinetic parameters for meranzin hydrate, naringenin, and hesperetin in rat plasma after oral administration of FA decoction at doses of 15 g/kg and 30 g/kg ().

Parameter	Meranzin hydrate		Naringenin		Hesperetin
	15 g/kg group	30 g/kg group	15 g/kg group	30 g/kg group	15 g/kg group	30 g/kg group
AUC(0–t) (g/L·h)	1534.84 ± 252.10	7370.77 ± 887.03	3662.98 ± 860.83	11176.77 ± 1413.17	508.31 ± 88.02	955.15 ± 226.98
MRT(0–t) (h)	2.77 ± 0.34	3.21 ± 0.22	4.06 ± 0.33	3.89 ± 0.21	4.27 ± 0.27	4.15 ± 0.35
t1/2z(h)	2.67 ± 0.81	2.23 ± 0.59	8.59 ± 9.25	5.67 ± 2.90	8.05 ± 3.10	6.56 ± 3.35
Tmax (h)	1.00 ± 0.27	1.25 ± 0.27	1.13 ± 0.35	0.81 ± 0.26	1.00 ± 0.38	1.31 ± 0.26
CL/F (L/h/kg)	9452.36 ± 1764.91	3875.84 ± 474.56	2816.64 ± 860.15	1986.11 ± 415.97	18224.53 ± 5230.06	21918.11 ± 6139.69
Cmax (µg/L)	504.75 ± 64.26	1827.68 ± 220.57	693.84 ± 208.24	2581.35 ± 388.30	83.90 ± 14.18	174.32 ± 39.04

, compared to 15 g/kg FA group.