Combination of Microwave-Assisted Girard Derivatization with Ionic Liquid Matrix for Sensitive MALDI-TOF MS Analysis of Human Serum N-Glycans

<div>Glycan derivatization chemistry and ionic liquid matrix. (a) Hydrazide reaction of Girard reagents with a hexose. GT = Girard’s reagent T (tetramethyl ammonium); GP = Girard’s reagent P (pyridium). (b) ILM formation of 2, 5-dihydroxybenzoic acid and aniline.</div>

Journal of Analytical Methods in Chemistry

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Scheme 1

Scheme 1: Combination of Microwave-Assisted Girard Derivatization with Ionic Liquid Matrix for Sensitive MALDI-TOF MS Analysis of Human Serum N-Glycans 

Scheme 1 | Combination of Microwave-Assisted Girard Derivatization with Ionic Liquid Matrix for Sensitive MALDI-TOF MS Analysis of Human Serum N-Glycans 