Analytical Method Development and Validation for the Quantification of Acetone and Isopropyl Alcohol in the Tartaric Acid Base Pellets of Dipyridamole Modified Release Capsules by Using Headspace Gas Chromatographic Technique

Table 9

Robustness data.

Parameter variation	The present relative standard deviation of peak area for six replicate injections should not more than 10.0		The present relative standard deviation of retention time for six replicate injections should not more than 10.0
	Acetone	Isopropyl alcohol	Acetone	Isopropyl alcohol
Flow 0.8 mL/min	0.4	0.6	0.0	0.0
Flow 1.2 mL/min	0.5	0.7	0.1	0.0
Column oven temperature 35°C	0.3	1.0	0.0	0.0
Column oven temperature 45°C	0.4	0.6	0.0	0.0
Headspace vial equilibration time 15 min	1.2	3.1	0.0	0.0
Headspace vial equilibration time 25 min	0.2	0.7	0.0	0.1
Headspace vial oven temperature 75°C	0.5	0.8	0.0	0.1
Headspace vial oven temperature 85°C	0.2	0.4	0.0	0.0