A Localized Surface Plasmon Resonance Sensing Method for Simultaneous Determination of Atenolol and Amiloride in Pharmaceutical Dosage Forms and Urine Samples
Table 5
Determination of ATN and AML in the pharmaceutical dosage form and in spiked urine sample.
Product
Drug (content, mg)
Found (mg)
Recovery (%) ± SD
F value
t value
Proposed method
Reported methoda
Atenoretic (capsules)
Atenolol, 50
49.8
48.0
3.205
0.233
99.6 ± 1.2
96 ± 2.0
2.444
0.127
Amiloride, 2.5
2.40
2.33
96.0 ± 0.8
93.2 ± 1.6
Spiked amount (mol·L−1)
Found amount (mol·L−1)
Recovery (%) ± SD
Urine sample
Atenolol, 1 × 10−4
0.99 × 10−4
99.0 ± 0.6
Amiloride, 0.5 × 10−5
0.48 × 10−5
96.0 ± 1.1
Average of three determinations ± SD. aReference [7].
