Development of Micellar HPLC-UV Method for Determination of Pharmaceuticals in Water Samples

Table 3

Main effects, interaction among the variables, and time of analysis.

Factor	Effects
	Rs (3-4)	Rs (4-5)	Rs (6–8)	Rs (8-9)	Rs (9-10)	Time of analysis
A-ethanol	0.190	0.310	−0.580	0.055	0.100	1.730
B-SDS	0.530	0.460	1.150	−1.070	−0.030	4.630
C-phosphate	0.520	−0.410	−0.950	−0.790	0.037	−0.170
AB	0.800	−0.520	−0.390	0.043	0.170	0.280
AC	−0.320	0.026	0.950	−0.390	−0.120	0.075
BC	0.096	−0.420	−0.820	0.590	0.110	−0.025
ABC	−0.029	−0.370	−0.320	0.240	−0.023	0.370
SD	±0.004	±0.048	±0.130	±0.005	±0.005	±0.048

Tetracycline (3), diclofenac (4), ibuprofen (5), 17α-ethynylestradiol (6), nimesulide (8) ciprofloxacin (9), and norfloxacin (10).