Journal of Analytical Methods in Chemistry / 2018 / Article / Tab 2

Research Article

Pharmacokinetics and UPLC-MS/MS of Delsoline in Mouse Whole Blood

Table 2

Pharmacokinetic parameters after delsoline administration in mice.

ParametersUnitig (9 mg/kg)ig (6 mg/kg)ig (3 mg/kg)iv (1 mg/kg)

AUC(0–t)ng/mLh570.1 ± 147.5271.9 ± 25.5128.4 ± 52.2241.4 ± 43.9
AUC(0–)ng/mLh571.0 ± 147.5272.9 ± 25.1129.9 ± 51.4242.4 ± 44.0
MRT(0–t)H0.7 ± 0.10.7 ± 0.11.1 ± 0.20.3 ± 0.1
MRT(0–)H0.7 ± 0.10.7 ± 0.11.2 ± 0.30.4 ± 0.1
t1/2zH1.3 ± 0.51.6 ± 0.71.7 ± 0.82.5 ± 0.7
CLz/FL/h/kg16.7 ± 4.422.1 ± 1.925.6 ± 8.34.2 ± 0.8
Vz/FL/kg33.1 ± 22.751.1 ± 23.067.8 ± 50.315.4 ± 4.5
Cmaxng/mL573.2 ± 124.9381.8 ± 70.8146.0 ± 56.8505.3 ± 69.5
Bioavailability26.2%18.8%17.7%

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