Chemometric-Assisted Spectrophotometric Method for the Simultaneous Determination of Ciprofloxacin and Doxycycline Hyclate in Pharmaceutical Formulations

Table 3

Accuracy data of CIP and DOX by PCR and PLS models ().

Mix.	Component	Level (%)	Amount taken (μg/mL)	PCR			PLS
				Predicted (μg/mL)	% recovery	% RSD	Predicted (μg/mL)	% recovery	% RSD
Mix. 1	CIP tablet	80	3.2	3.12	97.50	0.524	3.13	97.81	0.662
		100	4	3.91	97.75	0.869	3.90	97.50	0.794
		120	4.8	4.83	100.63	0.979	4.82	100.42	1.021
	DOX capsule	80	8	17.71	98.39	0.790	17.71	98.39	0.783
		100	10	20.23	101.15	0.941	20.24	101.20	0.933
		120	12	21.73	98.77	0.834	21.74	98.82	0.829
Mix. 2	CIP tablet	80	3.2	3.26	101.87	1.261	3.24	101.25	1.112
		100	4	3.93	98.25	0.634	3.92	98.00	0.751
		120	4.8	4.79	99.79	0.740	4.78	99.58	0.641
	DOX tablet	80	8	17.82	99.00	1.111	17.83	99.06	1.101
		100	10	20.19	100.95	0.799	20.2	101.00	0.791
		120	12	21.77	98.95	0.372	21.79	99.05	0.368