A New Electrochemical Sensor for Direct Detection of Purine Antimetabolites and DNA Degradation

Table 1

Main analytical results obtained for the voltammetric detection of the selected thiopurines using. GrO-IL-AuNPs-Chit/CSE (PBS, pH 7.4).

Analyte	, V	Regression equation ΔI (Ipa − Iblank), μA·vs. c (μmol·L^−1)	Linear range (µmol·L^−1)	LOD (μmol·L^−1) (S/N = 3)	Recovery, %
TG	+0.90 ± 0.02	ΔI = 4.215c + 0.045 (R^2 = 0.9989)	0–10	0.02	97.1–102.0
		ΔI = 1.528c + 0.083 (R^2 = 0.9998)	10–150		99.7–101.5
AZTP	+1.11 ± 0.01	ΔI = 2.660c + 0.056 (R^2 = 0.9991)	0–10	0.04	96.5–103.0
		ΔI = 1.859c + 0.091 (R^2 = 0.9991)	10–100		98.2–101.6
MP	−0.54 ± 0.01	ΔI = 2.790c + 0.036 (R^2 = 0.9990)	0–20	0.03	97.4–102.3
		ΔI = 0.938c + 0.065 (R^2 = 0.9994)	20–200		99.5–100.7

Accumulation time (t_acc): 120 s.